A new randomized controlled trial out of the UK that investigated 540 patients with ARDS from sepsis showed no benefit of statins. The study investigated the use of Simvastatin 80 mg/day vs placebo in patients with ARDS from sepsis and found no difference over placebo in 28-day mortality or ventilator-free days. There was an increase in myositis in the statin group.
McAuley DF et al. Simvastatin in the acute respiratory distress syndrome. N Engl J Med 2014 Sep 30; [e-pub ahead of print].