Historically, it was felt that a platelet count below 50,000 or an INR>1.5 was a contraindication to thoracentesis for an increased bleeding risk.  These were arbitrary cut-offs that have since been challenged with newer kits and the use of ultrasound-guided…
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The evidence base for the safety of ultrasound-guided central line placement with thrombocytopenia or in patients with a bleeding diathesis is not robust.  Nevertheless, based on the data available most procedural experts feels that an ultrasound-guided central venous catheter insertion…
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Traditionally, it has been promulgated by anesthesiologists that you need a platelet count of 100,000 to safely perform neuraxial regional anesthesia (spinal and epidural anesthesia).  This practice pattern has continued even though Children’s Hospitals routinely perform intrathecal injections for prophylactic chemotherapy with…
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