Septic Shock – Hospital Procedures Consultants

Continuous Infusion of Beta-Lactam Antibiotics is Superior to Intermittent Dosing for Sepsis

March 13, 2017

More Articles – antibiotics, beta-lactam antibiotics, HPC Updates, Sepsis, Septic Shock

More Tags – antibiotics, beta-lactam antibiotics, HPC updates, sepsis, septic shock

The bactericidal activity of antibiotics depends on the class of antibiotic used. Some antibiotics like vancomycin, aminoglycosides and fluoroquinolones are dose-dependent for their bactericidal activity. Other antibiotics like beta-lactam antibiotics are time-dependent antibiotics. Time-dependent antibiotics have increased bactericidal activity the…

Joseph Esherick, M.D., FAAFP, FHM

January 31, 2017

More Articles – ARDS, Arterial Lines, central lines, hemodynamic monitoring, HPC Updates, Mechanical Ventilation, Sepsis, Septic Shock, vasopressors

More Tags – ARDS, Arterial lines, central lines, hemodynamic monitoring, HPC updates, mechanical ventilation, sepsis, septic shock, vasopressors

Definitions Presumed source with SIRS criteria = infection Infection with life-threatening organ dysfunction = sepsis Sepsis refractory to intravenous fluid challenge = septic shock Treatment of sepsis or septic shock Draw blood cultures x 2 Analyze any fluid that may…

Continuous-Infusion Beta-Lactam Antibiotics is Superior to Intermittent Dosing in Septic Patients?

Joseph Esherick, M.D., FAAFP, FHM

January 9, 2017

More Articles – beta-lactam antibiotics, critical illness, HPC Updates, Sepsis, Septic Shock, severe sepsis

More Tags – beta-lactam antibiotics, critical illness, HPC updates, sepsis, septic shock, severe sepsis

The bactericidal activity of antibiotics depends on the class of antibiotic used. Some antibiotics like vancomycin, aminoglycosides and fluoroquinolones are dose-dependent for their bactericidal activity. Other antibiotics like beta-lactam antibiotics are time-dependent antibiotics which depend on maintaining drug concentrations above…

Joseph Esherick, M.D., FAAFP, FHM

December 1, 2014

More Articles – HPC Updates, Septic Shock

More Tags – HPC updates, septic shock

Steroids beneficial in refractory septic shock Preface: This multi-center observational study of over 1,800 patients examined whether low-dose steroids (<80 mg prednisone equivalents) was superior to placebo for patients in septic shock. There results showed that there was a slight…

Dr. Rick Rutherford, M.D., FAAFP

July 31, 2014

More Articles – Central Line, central line placement, Central Venous Catheter, HPC Updates, Procedure Blog of the Week, Sepsis, Septic Shock

More Tags – Central Line; Central Venous Catheter; Septic Shock; Sepsis; Early Goal Directed Therapy; ProCESS

In 2001, the Rivers trial showed that Early Goal Directed Therapy for septic shock resulted in a 16% absolute mortality risk reduction1. In the treatment arm of this trial, septic patients with a lactate above 4 mmol/L or systolic blood…

Joseph Esherick, M.D., FAAFP, FHM

October 31, 2011

More Articles – Sepsis, Septic Shock, Xigris

Drotrecogin-alfa (DrotAA) has been an integral part of the care bundle for adult patientshospitalized with severe sepsis or septic shock and a high risk of death since 2002. DrotAA is a synthetic activated Protein C (APC) which has good scientific…

Continuous Infusion of Beta-Lactam Antibiotics is Superior to Intermittent Dosing for Sepsis

Summary of Sepsis and Septic Shock Treatment in 2017

Continuous-Infusion Beta-Lactam Antibiotics is Superior to Intermittent Dosing in Septic Patients?

Steroids beneficial in refractory septic shock

Early Goal Directed Therapy for Sepsis: No Longer?

The Rise and Fall of Xigris (Drotrecogin-alfa)

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